Displaying drugs 1926 - 1932 of 1932 in total
Xylazine
Xylazine is a clonidine analog used as a non-opioid tranquilizer in veterinary medicine and as an emetic, especially in cats.[A9095,L42675,A251420] It acts as an agonist at α2 adrenoceptors; however, its affinity is lower than the one reported for other α2 adrenergic receptor agonists such as detomidine and medetomidine. Xylazine is...
Vet approved
Matched Description: … [A32545] Xylazine is not approved for human use and requires a veterinary licence for its purchase and ... [L42675] Xylazine is sometimes used as an adulterant and combined with opioids and recreational drugs ... [A9096] The use of xylazine can lead to hypotension and bradycardia[A9092,A9093], and when combined with …
Matched Categories: … Hypnotics and Sedatives …
Matched Categories: … Hypnotics and Sedatives …
UB-612
The UB-612 COVID-19 vaccine was developed by United Biomedical Inc Asia in Taipei as the first COVID-19 “multi-tope” protein-peptide vaccine made up of eight rationally designed components . The vaccine incorporates a strong S1-RBD component linked to a single chain fragment region (sFC) of a human IgG1, which facilitates cell...
Investigational
Matched Description: … vaccine incorporates a strong S1-RBD component linked to a single chain fragment region (sFC) of a human ... It was able to reduce viral load and prevent COVID-19 infection in a mouse challenge model and in rhesus ... IgG1, which facilitates cell attachment and acts as the principal neutralizing domain of the virus[L30658 …
NKG2D-ACE2 CAR-NK Cell
These cells are prepared as universal off-the-shelf CAR-NK cells from cord blood with NKG2D-ACE2 proteins engineered as part of the CARs; the cell secretes IL-15 and GM-CSF. Chimeric antigen receptors (CARs) are artificial receptors consisting of an antibody-derived antigen binding domain and transmembrane and signaling domains from T-cell receptor signalling...
Investigational
Matched Description: … First used with autologous human T cells (CAR-T) as cancer immunotherapies, these receptors are now being ... The transmembrane NKG2D and intracellular 2B4 domains are required for optimal NK signalling and subsequent ... transmembrane and signaling domains from T-cell receptor signalling moieties. …
Umbilical Cord Blood Hematopoietic Stem Cells
The use of umbilical cord blood (UCB) for therapies is advantageous because of its ease of access, non-invasive collection procedures, and more plasticity for multi-differentiation. UCB contains a large source of hematopoietic stem cells (HSCs) that are capable of self-renewal, have increased sensitivity to various factors, and are able to...
Investigational
Matched Description: … Specifically, the proliferation capacity of human umbilical cord blood mononuclear progenitor cells ( ... From the UCB, mononuclear cells are isolated and cultured in medium, expanded, and differentiated into ... of cytotoxicity and immunological reactions. …
Isoflavone
Isoflavone is a soy phytoestrogen and a biologically active component of several agriculturally important legumes such as soy, peanut, green peas, chick peas and alfalfa . Soybean is an exceptionally rich source of dietary isoflavones, where the average isoflavone content is 1-2 mg/gram . The main soy isoflavones are mostly...
Experimental
Matched Description: … The main soy isoflavones are mostly present in glycosylated forms and include [DB01645], [DB13182], and ... breast and prostate cancer [A33099]. ... legumes such as soy, peanut, green peas, chick peas and alfalfa [A33103]. …
Methoxyamine
Investigational
Cannabidivarin
Cannabidivarin, also known as cannabidivarol or CBDV, is a non-psychoactive cannabinoid found within DB14009. It is one of over 100 cannabinoids identified from the Cannabis plant that can modulate the physiological activity of cannabis, or marijuana . Compared to its homolog, DB09061, CBDV is shortened by two methyl (CH2) groups...
Investigational
Matched Description: … Notably, both [DB09061] and CBDV have demonstrated anticonvulsant activity in animal and human models ... CBD and CBDV have been shown to dose-dependently activate and then desensitize TRPV1 as well as TRPV2 ... and TRPA1 channels [A31560, A33334, A32976]. …
Displaying drugs 1926 - 1932 of 1932 in total