5-methoxy-N,N-dimethyltryptamine

DB14010IllicitInvestigationalSmall molecule

5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a tryptamine with psychedelic properties. It is found in a wide variety of plant species, and a single psychoactive toad species, the Colorado River toad. This drug,... This drug, as well as dimethyltryptamine and bufotenin, have been registered to be used in South America in religious and spiritual rituals.

Chemical structure of 5-methoxy-N,N-dimethyltryptamine
Formula / weight
C13H18N2O · 218.2948 g/mol (avg)
Also known as
5-MeO-DMT · MeODMT · Methoxybufotenin · O-methylbufotenine

Resolves to

Compound
UNIIX0MKX3GWU9CAS1019-45-0ChEMBLCHEMBL7257ChEBI2086KEGGC08309
Structure
InChIKeyZSTKHSQDNIGFLM-UHFFFAOYSA-NSMILESCOC1=CC=C2NC=C(CCN(C)C)C2=C1
Targets
P28335HTR2CP41595HTR2BP50406HTR6P08908HTR1AP28223HTR2A

What you can answer from here — as of April 23, 2025

5Protein targetsEach mapped to UniProt, with action and pharmacological action
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1,255Drug interactionsStructured to mechanism, not free text
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14Clinical trialsPhase, status and sponsor resolved per trial
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19+ReferencesStructured and connected to the statements they support
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Which drugs share a target with 5-methoxy-N,N-dimethyltryptamine, and which of those have an active Phase 3 trial?

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