5-hydroxytryptamine receptor 2B

BE0000393ProteinHumansHTR2B

G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:18703043, PubMed:23519210, PubMed:7926008, PubMed:8078486, PubMed:8143856, PubMed:8882600). It is acted on by 51 drugs in DrugBank.

Gene name
HTR2B
UniProtKB entry
P41595Swiss-Prot
Cellular location
Cell membrane
Residues / weight
481 residues · 54,297 Da
Also known as
5-HT-2B · 5-HT2B · Serotonin receptor 2B

Resolves to

Protein
UniProtP41595UniProt name5HT2B_HUMAN
Gene
HGNCHGNC:5294NCBI Gene3357GenBank475198GeneCardsHTR2B
Pharmacology
IUPHAR/GtoPdb7KEGGhsa:3357
Structure
PDB4IB4PDB4NC3PDB5TUD
Drugs

What you can answer from here — as of September 07, 2019

51DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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151+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 5-hydroxytryptamine receptor 2B, how selective are they, and which programs against it are still in active trials?

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