5-hydroxytryptamine receptor 2A

Details

Name
5-hydroxytryptamine receptor 2A
Kind
protein
Synonyms
  • 5-HT-2
  • 5-HT-2A
  • HTR2
  • Serotonin receptor 2A
Gene Name
HTR2A
UniProtKB Entry
P28223Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0000899|5-hydroxytryptamine receptor 2A
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
Number of residues
471
Molecular Weight
52602.58
Theoretical pI
7.72
GO Classification
Functions
G protein-coupled serotonin receptor activity / Gq/11-coupled serotonin receptor activity / identical protein binding / neurotransmitter receptor activity / protein tyrosine kinase activator activity / protein-containing complex binding
Processes
chemical synaptic transmission / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / G protein-coupled serotonin receptor signaling pathway / glycolytic process / intracellular calcium ion homeostasis / phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of cell population proliferation / positive regulation of cytokine production involved in immune response / positive regulation of cytosolic calcium ion concentration / positive regulation of DNA biosynthetic process / positive regulation of execution phase of apoptosis / positive regulation of heat generation / positive regulation of inflammatory response / positive regulation of neuron apoptotic process / positive regulation of platelet aggregation / presynaptic modulation of chemical synaptic transmission / response to xenobiotic stimulus / sensitization
Components
cytoplasmic vesicle / dendrite / G protein-coupled serotonin receptor complex / glutamatergic synapse / neurofilament / postsynaptic membrane / presynaptic membrane
General Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895, PubMed:21645528, PubMed:22300836, PubMed:35084960, PubMed:38552625). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538, PubMed:35084960). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:28129538, PubMed:35084960). HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (PubMed:18703043, PubMed:28129538, PubMed:35084960). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538, PubMed:35084960). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity)
Specific Function
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
81-97 112-137 147-171 192-215 233-258 323-348 357-382
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0020465|5-hydroxytryptamine receptor 2A (HTR2A)
ATGGATATTCTTTGTGAAGAAAATACTTCTTTGAGCTCAACTACGAACTCCCTAATGCAA
TTAAATGATGACACCAGGCTCTACAGTAATGACTTTAACTCCGGAGAAGCTAACACTTCT
GATGCATTTAACTGGACAGTCGACTCTGAAAATCGAACCAACCTTTCCTGTGAAGGGTGC
CTCTCACCGTCGTGTCTCTCCTTACTTCATCTCCAGGAAAAAAACTGGTCTGCTTTACTG
ACAGCCGTAGTGATTATTCTAACTATTGCTGGAAACATACTCGTCATCATGGCAGTGTCC
CTAGAGAAAAAGCTGCAGAATGCCACCAACTATTTCCTGATGTCACTTGCCATAGCTGAT
ATGCTGCTGGGTTTCCTTGTCATGCCCGTGTCCATGTTAACCATCCTGTATGGGTACCGG
TGGCCTCTGCCGAGCAAGCTTTGTGCAGTCTGGATTTACCTGGACGTGCTCTTCTCCACG
GCCTCCATCATGCACCTCTGCGCCATCTCGCTGGACCGCTACGTCGCCATCCAGAATCCC
ATCCACCACAGCCGCTTCAACTCCAGAACTAAGGCATTTCTGAAAATCATTGCTGTTTGG
ACCATATCAGTAGGTATATCCATGCCAATACCAGTCTTTGGGCTACAGGACGATTCGAAG
GTCTTTAAGGAGGGGAGTTGCTTACTCGCCGATGATAACTTTGTCCTGATCGGCTCTTTT
GTGTCATTTTTCATTCCCTTAACCATCATGGTGATCACCTACTTTCTAACTATCAAGTCA
CTCCAGAAAGAAGCTACTTTGTGTGTAAGTGATCTTGGCACACGGGCCAAATTAGCTTCT
TTCAGCTTCCTCCCTCAGAGTTCTTTGTCTTCAGAAAAGCTCTTCCAGCGGTCGATCCAT
AGGGAGCCAGGGTCCTACACAGGCAGGAGGACTATGCAGTCCATCAGCAATGAGCAAAAG
GCATGCAAGGTGCTGGGCATCGTCTTCTTCCTGTTTGTGGTGATGTGGTGCCCTTTCTTC
ATCACAAACATCATGGCCGTCATCTGCAAAGAGTCCTGCAATGAGGATGTCATTGGGGCC
CTGCTCAATGTGTTTGTTTGGATCGGTTATCTCTCTTCAGCAGTCAACCCACTAGTCTAC
ACACTGTTCAACAAGACCTATAGGTCAGCCTTTTCACGGTATATTCAGTGTCAGTACAAG
GAAAACAAAAAACCATTGCAGTTAATTTTAGTGAACACAATACCGGCTTTGGCCTACAAG
TCTAGCCAACTTCAAATGGGACAAAAAAAGAATTCAAAGCAAGATGCCAAGACAACAGAT
AATGACTGCTCAATGGTTGCTCTAGGAAAGCAGCATTCTGAAGAGGCTTCTAAAGACAAT
AGCGACGGAGTGAATGAAAAGGTGAGCTGTGTGTGA
Chromosome Location
13
Locus
13q14.2
External Identifiers
ResourceLink
UniProtKB IDP28223
UniProtKB Entry Name5HT2A_HUMAN
GenBank Protein ID36431
GenBank Gene IDS42168
GeneCard IDHTR2A
GenAtlas IDHTR2A
HGNC IDHGNC:5293
PDB ID(s)6A93, 6A94, 6WGT, 6WH4, 6WHA, 7RAN, 7VOD, 7VOE, 7WC4, 7WC5, 7WC6, 7WC7, 7WC8, 7WC9, 8JT8, 8UWL, 8V6U
KEGG IDhsa:3356
IUPHAR/Guide To Pharmacology ID6
NCBI Gene ID3356
General References
  1. Saltzman AG, Morse B, Whitman MM, Ivanshchenko Y, Jaye M, Felder S: Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes. Biochem Biophys Res Commun. 1991 Dec 31;181(3):1469-78. [Article]
  2. Chen K, Yang W, Grimsby J, Shih JC: The human 5-HT2 receptor is encoded by a multiple intron-exon gene. Brain Res Mol Brain Res. 1992 Jun;14(1-2):20-6. [Article]
  3. Cook EH Jr, Fletcher KE, Wainwright M, Marks N, Yan SY, Leventhal BL: Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor. J Neurochem. 1994 Aug;63(2):465-9. [Article]
  4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  5. Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, Dunham I, Dunn M, Earthrowl ME, Ellington AG, Faulkner L, Frankish AG, Frankland J, French L, Garner P, Garnett J, Gilbert JG, Gilson CJ, Ghori J, Grafham DV, Gribble SM, Griffiths C, Hall RE, Hammond S, Harley JL, Hart EA, Heath PD, Howden PJ, Huckle EJ, Hunt PJ, Hunt AR, Johnson C, Johnson D, Kay M, Kimberley AM, King A, Laird GK, Langford CJ, Lawlor S, Leongamornlert DA, Lloyd DM, Lloyd C, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, McLaren SJ, McMurray A, Milne S, Moore MJ, Nickerson T, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter KM, Rice CM, Searle S, Sehra HK, Shownkeen R, Skuce CD, Smith M, Steward CA, Sycamore N, Tester J, Thomas DW, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Wilming L, Wray PW, Wright MW, Young L, Coulson A, Durbin R, Hubbard T, Sulston JE, Beck S, Bentley DR, Rogers J, Ross MT: The DNA sequence and analysis of human chromosome 13. Nature. 2004 Apr 1;428(6982):522-8. [Article]
  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  7. Stam NJ, Van Huizen F, Van Alebeek C, Brands J, Dijkema R, Tonnaer JA, Olijve W: Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes. Eur J Pharmacol. 1992 Oct 1;227(2):153-62. [Article]
  8. Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C: Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. J Biol Chem. 2001 Apr 20;276(16):12974-82. Epub 2001 Jan 9. [Article]
  9. Becamel C, Gavarini S, Chanrion B, Alonso G, Galeotti N, Dumuis A, Bockaert J, Marin P: The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins. J Biol Chem. 2004 May 7;279(19):20257-66. Epub 2004 Feb 26. [Article]
  10. Nichols DE, Nichols CD: Serotonin receptors. Chem Rev. 2008 May;108(5):1614-41. doi: 10.1021/cr078224o. Epub 2008 May 14. [Article]
  11. Cussac D, Boutet-Robinet E, Ailhaud MC, Newman-Tancredi A, Martel JC, Danty N, Rauly-Lestienne I: Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. Eur J Pharmacol. 2008 Oct 10;594(1-3):32-8. doi: 10.1016/j.ejphar.2008.07.040. Epub 2008 Jul 30. [Article]
  12. Gonzalez-Maeso J, Ang RL, Yuen T, Chan P, Weisstaub NV, Lopez-Gimenez JF, Zhou M, Okawa Y, Callado LF, Milligan G, Gingrich JA, Filizola M, Meana JJ, Sealfon SC: Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature. 2008 Mar 6;452(7183):93-7. doi: 10.1038/nature06612. Epub 2008 Feb 24. [Article]
  13. Knauer CS, Campbell JE, Chio CL, Fitzgerald LW: Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors. Naunyn Schmiedebergs Arch Pharmacol. 2009 May;379(5):461-71. doi: 10.1007/s00210-008-0378-4. Epub 2008 Dec 5. [Article]
  14. Albizu L, Holloway T, Gonzalez-Maeso J, Sealfon SC: Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors. Neuropharmacology. 2011 Sep;61(4):770-7. doi: 10.1016/j.neuropharm.2011.05.023. Epub 2011 May 27. [Article]
  15. Pytliak M, Vargova V, Mechirova V, Felsoci M: Serotonin receptors - from molecular biology to clinical applications. Physiol Res. 2011;60(1):15-25. Epub 2010 Oct 15. [Article]
  16. Delille HK, Becker JM, Burkhardt S, Bleher B, Terstappen GC, Schmidt M, Meyer AH, Unger L, Marek GJ, Mezler M: Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades. Neuropharmacology. 2012 Jun;62(7):2184-91. doi: 10.1016/j.neuropharm.2012.01.010. Epub 2012 Jan 25. [Article]
  17. Karaki S, Becamel C, Murat S, Mannoury la Cour C, Millan MJ, Prezeau L, Bockaert J, Marin P, Vandermoere F: Quantitative phosphoproteomics unravels biased phosphorylation of serotonin 2A receptor at Ser280 by hallucinogenic versus nonhallucinogenic agonists. Mol Cell Proteomics. 2014 May;13(5):1273-85. doi: 10.1074/mcp.M113.036558. Epub 2014 Mar 17. [Article]
  18. Assetta B, Maginnis MS, Gracia Ahufinger I, Haley SA, Gee GV, Nelson CD, O'Hara BA, Allen Ramdial SA, Atwood WJ: 5-HT2 receptors facilitate JC polyomavirus entry. J Virol. 2013 Dec;87(24):13490-8. doi: 10.1128/JVI.02252-13. Epub 2013 Oct 2. [Article]
  19. Erdmann J, Shimron-Abarbanell D, Rietschel M, Albus M, Maier W, Korner J, Bondy B, Chen K, Shih JC, Knapp M, Propping P, Nothen MM: Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia. Hum Genet. 1996 May;97(5):614-9. [Article]
  20. Marshall SE, Bird TG, Hart K, Welsh KI: Unified approach to the analysis of genetic variation in serotonergic pathways. Am J Med Genet. 1999 Dec 15;88(6):621-7. [Article]
  21. Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES: Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet. 1999 Jul;22(3):231-8. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
MethysergideapprovedyestargetantagonistDetails
MirtazapineapprovedyestargetantagonistDetails
CyproheptadineapprovedyestargetantagonistDetails
Trazodoneapproved, investigationalyestargetantagonistDetails
CyclobenzaprineapprovedyestargetantagonistDetails
Nefazodoneapproved, withdrawnyestargetantagonistDetails
QuetiapineapprovedyestargetantagonistDetails
ZiprasidoneapprovedyestargetantagonistDetails
Olanzapineapproved, investigationalyestargetantagonistDetails
ClozapineapprovedyestargetantagonistDetails
Promazineapproved, vet_approvedunknowntargetantagonistDetails
Chlorpromazineapproved, investigational, vet_approvedyestargetantagonistDetails
Thioridazineapproved, withdrawnyestargetantagonistDetails
PropiomazineapprovedunknowntargetantagonistDetails
MinaprineapprovedyestargetantagonistDetails
Mesoridazineapproved, investigationalyestargetantagonistDetails
Aripiprazoleapproved, investigationalyestargetantagonistDetails
PaliperidoneapprovedyestargetantagonistDetails
ErgotamineapprovedyestargetagonistDetails
Paroxetineapproved, investigationalunknowntargetagonistDetails
DonepezilapprovedunknowntargetinducerDetails
Clomipramineapproved, investigational, vet_approvedyestargetantagonistDetails
MMDAexperimental, illicityestargetagonistDetails
Chlorprothixeneapproved, experimental, investigational, withdrawnyestargetantagonistDetails
Epinastineapproved, investigationalunknowntargetantagonistDetails
APD791investigationalunknowntargetDetails
Sertindoleapproved, investigational, withdrawnyestargetantagonistDetails
Flibanserinapproved, investigationalyestargetantagonistDetails
NelotanserininvestigationalyestargetmodulatorDetails
Mianserinapproved, investigationalunknowntargetantagonistDetails
HY10275investigationalunknowntargetDetails
Pimavanserinapproved, investigationalyestargetinverse agonistDetails
IloperidoneapprovedyestargetantagonistDetails
BL-1020investigationalunknowntargetDetails
Epicept NP-1investigationalunknowntargetDetails
Cisaprideapproved, investigational, withdrawnyestargetagonistDetails
Lumateperoneapproved, investigationalyestargetantagonistDetails
YKP-1358investigationalunknowntargetDetails
AsenapineapprovedyestargetantagonistDetails
OcaperidoneinvestigationalyestargetmodulatorDetails
EplivanserininvestigationalunknowntargetDetails
DeramciclaneinvestigationalunknowntargetantagonistDetails
AniracetamexperimentalyestargetinhibitorDetails
DotarizineinvestigationalunknowntargetDetails
Pergolideapproved, investigational, vet_approved, withdrawnunknowntargetagonistDetails
Bromocriptineapproved, investigational, withdrawnunknowntargetagonistDetails
Lisurideapproved, investigationalyestargetagonistDetails
CabergolineapprovedunknowntargetagonistDetails
Apomorphineapproved, investigationalunknowntargetagonistDetails
Flupentixolapproved, investigational, withdrawnyestargetantagonistDetails
Haloperidolapprovedunknowntargetother/unknownDetails
Methotrimeprazineapproved, investigationalunknowntargetantagonistDetails
MolindoneapprovedunknowntargetantagonistDetails
Dimethyltryptamineexperimental, illicityestargetinhibitorDetails
Zuclopenthixolapproved, investigationalunknowntargetantagonistDetails
LoxapineapprovedyestargetantagonistDetails
AmitriptylineapprovedyestargetantagonistDetails
Doxepinapproved, investigationalunknowntargetantagonistDetails
Desipramineapproved, investigationalyestargetantagonistDetails
ImipramineapprovedunknowntargetantagonistDetails
NortriptylineapprovedyestargetantagonistDetails
Remoxiprideapproved, withdrawnunknowntargetother/unknownDetails
TrimipramineapprovedunknowntargetagonistDetails
Yohimbineapproved, investigational, vet_approvedunknowntargetantagonistDetails
Tegaserodapproved, investigational, withdrawnunknowntargetantagonistDetails
Fluspirileneapproved, investigationalunknowntargetantagonistDetails
Amisulprideapproved, investigationalyestargetantagonistDetails
Acepromazineexperimental, vet_approvedyestargetantagonistDetails
Pipotiazineapproved, investigationalyestargetantagonistDetails
ThiothixeneapprovedunknowntargetantagonistDetails
Midomafetamineexperimental, illicit, investigationalyestargetagonistDetails
CinitaprideinvestigationalyestargetantagonistDetails
Lurasidoneapproved, investigationalyestargetantagonistDetails
AmperozideexperimentalunknowntargetantagonistDetails
AmoxapineapprovedunknowntargetantagonistDetails
Maprotilineapproved, investigationalunknowntargetbinderDetails
Butriptylineapproved, withdrawnyestargetantagonistDetails
Brexpiprazoleapproved, investigationalunknowntargetantagonistDetails
Perospironeexperimentalyestargetinverse agonistDetails
DosulepinapprovedyestargetantagonistDetails
Fenfluramineapproved, illicit, investigational, withdrawnunknowntargetagonistDetails
Serotonininvestigational, nutraceuticalyestargetinhibitorDetails
Ketanserininvestigationalunknowntargetinverse agonistDetails
Ritanserininvestigationalunknowntargetinverse agonistDetails
Sarpogrelateinvestigationalunknowntargetinverse agonistDetails
FluphenazineapprovedunknowntargetDetails
4-Bromo-2,5-dimethoxyphenethylamineexperimental, illicitunknowntargetpartial agonistDetails
EtoperidonewithdrawnyestargetantagonistDetails
BlonanserininvestigationalyestargetantagonistDetails
2,5-Dimethoxy-4-ethylthioamphetamineexperimentalunknowntargetagonistDetails
Cannabidiolapproved, investigationalunknowntargetagonistDetails
N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamineexperimentalunknowntargetagonistDetails
LorpiprazoleapprovedyestargetantagonistDetails
Lamotrigineapproved, investigationalunknowntargetinhibitorDetails
Zotepineapproved, investigational, withdrawnyestargetantagonistDetails
PipamperoneinvestigationalunknowntargetagonistDetails
PizotifenapprovedunknowntargetantagonistDetails
5-methoxy-N,N-dimethyltryptamineexperimental, illicitunknowntargetagonistDetails
NabiximolsinvestigationalunknowntargetDetails
Medical Cannabisexperimental, investigationalunknowntargetDetails
Aripiprazole lauroxilapproved, investigationalyestargetantagonistDetails
EscitalopramapprovedunknowntargetinhibitorDetails
Risperidoneapproved, investigationalyestargetantagonistDetails
Zolmitriptanapproved, investigationalnotargetagonistDetails
VolinanserininvestigationalyestargetantagonistDetails
Dihydroergotamineapproved, investigationalunknowntargetagonistDetails
Cariprazineapproved, investigationalunknowntargetantagonistDetails
m-ChlorophenylpiperazineinvestigationalyestargetagonistDetails
CyamemazineexperimentalyestargetantagonistDetails
Bufotenineexperimental, illicityestargetantagonistDetails
SpiperoneinvestigationalyestargetinhibitorDetails
2,5-Dimethoxyamphetamineexperimental, illicityestargetinhibitorDetails
MescalineinvestigationalyestargetinhibitorDetails
4-Bromo-2,5-dimethoxyamphetamineexperimental, illicityestargetinhibitorDetails
FluanisoneexperimentalyestargetinhibitorDetails
PhenethylamineexperimentalyestargetinhibitorDetails
4-Methyl-2,5-dimethoxyamphetamineexperimental, illicityestargetinhibitorDetails
2,5-Dimethoxy-4-ethylamphetamineexperimental, illicityestargetinhibitorDetails
LubazodoneexperimentalyestargetinhibitorDetails
TrelanserininvestigationalyestargetmodulatorDetails
Lysergic acid diethylamideillicit, investigational, withdrawnyestargetinhibitorDetails
PruvanserininvestigationalyestargetmodulatorDetails
LandipirdineinvestigationalyestargetantagonistDetails
RoluperidoneinvestigationalyestargetantagonistDetails
ZicronapineinvestigationalyestargetmodulatorDetails
MetergolineapprovedyestargetantagonistDetails
TryptamineexperimentalyestargetinhibitorDetails