Cyclic nucleotide phosphodiesterases.

Article Details

Citation

Copy to clipboard

Essayan DM

Cyclic nucleotide phosphodiesterases.

J Allergy Clin Immunol. 2001 Nov;108(5):671-80.

PubMed ID

11692087 [ View in PubMed

]

Abstract

Cyclic nucleotide second messengers (cAMP and cGMP) play a central role in signal transduction and regulation of physiologic responses. Their intracellular levels are controlled by the complex superfamily of cyclic nucleotide phosphodiesterase (PDE) enzymes. Continuing advances in our understanding of the molecular pharmacology of these enzymes has led to the development of selective inhibitors as therapeutic agents for disease states ranging from cancer and heart failure to depression and sexual dysfunction. Several PDE types have been identified as therapeutic targets for immune/inflammatory diseases. This article briefly reviews the available in vitro, preclinical, and clinical data supporting the potential for selective PDE inhibitors as immunomodulatory agents.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Caffeine	Cyclic nucleotide phosphodiesterase (Protein Group)	Protein group	Humans	Unknown	Inhibitor	Details
Theobromine	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Protein	Humans	Unknown	Inhibitor	Details