Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent.
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Munk SA, Lai RK, Burke JE, Arasasingham PN, Kharlamb AB, Manlapaz CA, Padillo EU, Wijono MK, Hasson DW, Wheeler LA, Garst ME
Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent.
J Med Chem. 1996 Mar 15;39(6):1193-5.
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- 8632424 [ View in PubMed]
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- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Clonidine Alpha-2A adrenergic receptor Ki (nM) 3.8 N/A N/A Details Clonidine Alpha-2C adrenergic receptor Ki (nM) 30 N/A N/A Details Norepinephrine Alpha-2A adrenergic receptor Ki (nM) 66 N/A N/A Details Norepinephrine Alpha-2C adrenergic receptor Ki (nM) 63 N/A N/A Details