Novel benzimidazole derivatives as selective CB2 agonists.
Article Details
- CitationCopy to clipboard
Page D, Balaux E, Boisvert L, Liu Z, Milburn C, Tremblay M, Wei Z, Woo S, Luo X, Cheng YX, Yang H, Srivastava S, Zhou F, Brown W, Tomaszewski M, Walpole C, Hodzic L, St-Onge S, Godbout C, Salois D, Payza K
Novel benzimidazole derivatives as selective CB2 agonists.
Bioorg Med Chem Lett. 2008 Jul 1;18(13):3695-700. doi: 10.1016/j.bmcl.2008.05.073. Epub 2008 May 22.
- PubMed ID
- 18522867 [ View in PubMed]
- Abstract
The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported. They showed binding affinities up to 1nM towards the CB2 receptor with partial to full agonist potencies. They also demonstrated good to excellent selectivity (>1000-fold) over the CB1 receptor.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Dronabinol Cannabinoid receptor 1 Ki (nM) 2.9 N/A N/A Details Dronabinol Cannabinoid receptor 2 Ki (nM) 41 N/A N/A Details Dronabinol Cannabinoid receptor 2 EC 50 (nM) 1.5 N/A N/A Details