N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor.

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Jonathan Fray M, Bish G, Brown AD, Fish PV, Stobie A, Wakenhut F, Whitlock GA

N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor.

Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. Epub 2006 Jun 5.

PubMed ID
16750359 [ View in PubMed
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Abstract

The synthesis and structure-activity relationships of a novel series of piperazine derivatives as dual inhibitors of serotonin and noradrenaline reuptake is described. Two compounds possessed comparable in vitro profiles to the dual reuptake inhibitor duloxetine.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
DuloxetineSodium-dependent dopamine transporterIC 50 (nM)870N/AN/ADetails
DuloxetineSodium-dependent noradrenaline transporterIC 50 (nM)19N/AN/ADetails
DuloxetineSodium-dependent serotonin transporterIC 50 (nM)6N/AN/ADetails
FluoxetineSodium-dependent serotonin transporterIC 50 (nM)16N/AN/ADetails