Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH.

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Watkins WJ, Chen JM, Cho A, Chong L, Collins N, Fardis M, Huang W, Hung M, Kirschberg T, Lee WA, Liu X, Thomas W, Xu J, Zeynalzadegan A, Zhang J

Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3479-83. Epub 2006 Apr 18.

PubMed ID

16621550 [ View in PubMed

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Abstract

The design, synthesis, and IMPDH inhibitory activity of a series of phosphonic acid-containing analogues of mycophenolic acid are described.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Mycophenolic acid	Inosine-5'-monophosphate dehydrogenase 1	IC 50 (nM)	32	N/A	N/A	Details
Mycophenolic acid	Inosine-5'-monophosphate dehydrogenase 2	IC 50 (nM)	11	N/A	N/A	Details