Inosine-5'-monophosphate dehydrogenase 1

BE0000761ProteinHumansIMPDH1

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of... It is acted on by 16 drugs in DrugBank.

Gene name
IMPDH1
UniProtKB entry
P20839Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
514 residues · 55,405 Da
Also known as
1.1.1.205 · IMP dehydrogenase 1 · IMPD 1 · IMPD1 · IMPDH 1

Resolves to

Protein
UniProtP20839UniProt nameIMDH1_HUMAN
Gene
HGNCHGNC:6052NCBI Gene3614GenBank307067GeneCardsIMPDH1
Pharmacology
IUPHAR/GtoPdb2624KEGGhsa:3614
Structure
PDB1JCNPDB7RERPDB7RES
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Inosine-5'-monophosphate dehydrogenase 1, how selective are they, and which programs against it are still in active trials?

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