Ganaxolone.
Article Details
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Nohria V, Giller E
Ganaxolone.
Neurotherapeutics. 2007 Jan;4(1):102-5.
- PubMed ID
- 17199022 [ View in PubMed]
- Abstract
Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one) (GNX) is the 3beta-methylated synthetic analog of allopregnanolone; it belongs to a class of compounds referred to as neurosteroids. GNX is an allosteric modulator of GABA(A) receptors acting through binding sites which are distinct from the benzodiazepine binding site. It has activity in a broad range of animal models of epilepsy. GNX has been shown to be well tolerated in adults and children. In early phase II studies, GNX has been shown to have activity in adult patients with partial-onset seizures and epileptic children with history of infantile spasms. It is currently undergoing further development in infants with newly diagnosed infantile spasms, in women with catamenial epilepsy, and in adults with refractory partial-onset seizures.
DrugBank Data that Cites this Article
- Drugs
- Drug Reactions
Reaction Details - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareGanaxoloneBexarotene The metabolism of Ganaxolone can be increased when combined with Bexarotene. GanaxoloneBosentan The metabolism of Ganaxolone can be increased when combined with Bosentan. GanaxoloneNafcillin The metabolism of Ganaxolone can be increased when combined with Nafcillin. GanaxoloneEfavirenz The metabolism of Ganaxolone can be increased when combined with Efavirenz. GanaxoloneModafinil The metabolism of Ganaxolone can be increased when combined with Modafinil.
