Complete genome sequence of a virulent isolate of Streptococcus pneumoniae.

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Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, Peterson S, Heidelberg J, DeBoy RT, Haft DH, Dodson RJ, Durkin AS, Gwinn M, Kolonay JF, Nelson WC, Peterson JD, Umayam LA, White O, Salzberg SL, Lewis MR, Radune D, Holtzapple E, Khouri H, Wolf AM, Utterback TR, Hansen CL, McDonald LA, Feldblyum TV, Angiuoli S, Dickinson T, Hickey EK, Holt IE, Loftus BJ, Yang F, Smith HO, Venter JC, Dougherty BA, Morrison DA, Hollingshead SK, Fraser CM

Complete genome sequence of a virulent isolate of Streptococcus pneumoniae.

Science. 2001 Jul 20;293(5529):498-506.

PubMed ID
11463916 [ View in PubMed
]
Abstract

The 2,160,837-base pair genome sequence of an isolate of Streptococcus pneumoniae, a Gram-positive pathogen that causes pneumonia, bacteremia, meningitis, and otitis media, contains 2236 predicted coding regions; of these, 1440 (64%) were assigned a biological role. Approximately 5% of the genome is composed of insertion sequences that may contribute to genome rearrangements through uptake of foreign DNA. Extracellular enzyme systems for the metabolism of polysaccharides and hexosamines provide a substantial source of carbon and nitrogen for S. pneumoniae and also damage host tissues and facilitate colonization. A motif identified within the signal peptide of proteins is potentially involved in targeting these proteins to the cell surface of low-guanine/cytosine (GC) Gram-positive species. Several surface-exposed proteins that may serve as potential vaccine candidates were identified. Comparative genome hybridization with DNA arrays revealed strain differences in S. pneumoniae that could contribute to differences in virulence and antigenicity.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Penicillin-binding protein 2BP0A3M5Details
Hyaluronate lyaseQ54873Details
3-phosphoshikimate 1-carboxyvinyltransferaseQ9S400Details
AutolysinP06653Details
Penicillin-binding protein 2xP14677Details
Uncharacterized proteinA0A0H2URW2Details
Bifunctional protein GlmUQ97R46Details
LicC proteinA0A0H2UQB5Details
Penicillin-binding protein 1AQ04707Details
DNA gyrase subunit AP72524Details
DNA gyrase subunit BP0A4L9Details
DNA topoisomerase 4 subunit AP72525Details
DNA topoisomerase 4 subunit BQ59961Details
50S ribosomal protein L22P61182Details