Coagulation factor XIII A chain

BE0000004ProteinHumansF13A1

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. It is acted on by 8 drugs in DrugBank.

Gene name
F13A1
UniProtKB entry
P00488Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
732 residues · 83,268 Da
Also known as
2.3.2.13 · Coagulation factor XIIIa · F13A · Protein-glutamine gamma-glutamyltransferase A chain · Transglutaminase A chain

Resolves to

Protein
UniProtP00488UniProt nameF13A_HUMAN
Gene
HGNCHGNC:3531NCBI Gene2162GenBank182309GeneCardsF13A1
Pharmacology
KEGGhsa:2162
Structure
PDB1EVUPDB1EX0PDB1F13
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Coagulation factor XIII A chain, how selective are they, and which programs against it are still in active trials?

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