Glycogen phosphorylase, liver form

BE0000007ProteinHumansPYGL

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. It is acted on by 15 drugs in DrugBank.

Gene name
PYGL
UniProtKB entry
P06737Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
847 residues · 97,148 Da
Also known as
2.4.1.1

Resolves to

Protein
UniProtP06737UniProt namePYGL_HUMAN
Gene
HGNCHGNC:9725NCBI Gene5836GenBank183353GeneCardsPYGL
Pharmacology
KEGGhsa:5836
Structure
PDB1EM6PDB1EXVPDB1FA9
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glycogen phosphorylase, liver form, how selective are they, and which programs against it are still in active trials?

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