5-hydroxytryptamine receptor 4

BE0000084ProteinHumansHTR4

G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:10821780, PubMed:16102731, PubMed:35714614, PubMed:9603189). It is acted on by 33 drugs in DrugBank.

Gene name
HTR4
UniProtKB entry
Q13639Swiss-Prot
Cellular location
Cell membrane
Residues / weight
388 residues · 43,761 Da
Also known as
5-HT-4 · 5-HT4 · Serotonin receptor 4

Resolves to

Protein
UniProtQ13639UniProt name5HT4R_HUMAN
Gene
HGNCHGNC:5299NCBI Gene3360GenBank2661757GeneCardsHTR4
Pharmacology
IUPHAR/GtoPdb9KEGGhsa:3360
Structure
PDB5EM9PDB7XT8PDB7XT9
Drugs

What you can answer from here — as of September 07, 2019

33DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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116+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 5-hydroxytryptamine receptor 4, how selective are they, and which programs against it are still in active trials?

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