Aldo-keto reductase family 1 member C1

BE0000126ProteinHumansAKR1C1

Cytosolic aldo-keto reductase that catalyzes NADPH-dependent reduction of ketosteroids to hydroxysteroids. It is acted on by 14 drugs in DrugBank.

Gene name
AKR1C1
UniProtKB entry
Q04828Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
323 residues · 36,788 Da
Also known as
1.1.1.- · 1.1.1.112 · 1.1.1.209 · 1.1.1.210 · 1.1.1.357

Resolves to

Protein
UniProtQ04828UniProt nameAK1C1_HUMAN
Gene
HGNCHGNC:384NCBI Gene1645GenBank181549GeneCardsAKR1C1
Pharmacology
KEGGhsa:1645
Structure
PDB1MRQPDB3C3UPDB3GUG
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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5Metabolic reactionsDrug transformations it catalyses, substrate to product
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aldo-keto reductase family 1 member C1, how selective are they, and which programs against it are still in active trials?

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