Dopamine beta-hydroxylase

BE0000138ProteinHumansDBH

Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters. It is acted on by 15 drugs in DrugBank.

Gene name
DBH
UniProtKB entry
P09172Swiss-Prot
Cellular location
Cytoplasmic vesicle, secretory vesicle lumen
Residues / weight
617 residues · 69,064 Da
Also known as
1.14.17.1 · Dopamine beta-monooxygenase

Resolves to

Protein
UniProtP09172UniProt nameDOPO_HUMAN
Gene
HGNCHGNC:2689NCBI Gene1621GenBank30474GeneCardsDBH
Pharmacology
IUPHAR/GtoPdb2486KEGGhsa:1621
Structure
PDB4ZEL
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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46+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dopamine beta-hydroxylase, how selective are they, and which programs against it are still in active trials?

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