Dopamine receptor D5

BE0000145ProteinHumansDRD5

G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (PubMed:11500503, PubMed:1826762, PubMed:1834671, PubMed:37221270). It is acted on by 23 drugs in DrugBank.

Gene name
DRD5
UniProtKB entry
P21918Swiss-Prot
Cellular location
Cell membrane
Residues / weight
477 residues · 52,951 Da
Also known as
D(1B) dopamine receptor · D(5) dopamine receptor · D1beta dopamine receptor · Dopamine D5 receptor · DRD1B

Resolves to

Protein
UniProtP21918UniProt nameDRD5_HUMAN
Gene
HGNCHGNC:3026NCBI Gene1816GenBank32049GeneCardsDRD5
Pharmacology
IUPHAR/GtoPdb218KEGGhsa:1816
Structure
PDB8IRV
Drugs

What you can answer from here — as of September 08, 2026

23DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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69+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dopamine receptor D5, how selective are they, and which programs against it are still in active trials?

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