Lisuride

DB00589ApprovedSmall molecule

An ergot derivative that acts as an agonist at dopamine D2 receptors (dopamine agonists). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at...

Mechanism: Lisuride is an anti-Parkinson drug chemically related to the dopaminergic ergoline Parkinson's drugs. Lisuride binds to the 5-HT(1A) and 5-HT(2A/2C) receptors. It is also thought to bind to the dopamine receptor and to act as a dopamine agonist. Evidence has also emerged that Lisuride also binds to the Histamine H1 receptor.
Curator reviewed
Primary indication: For the management of Parkinson's DiseaseCurator reviewed
Formula / weight: C₂₀H₂₆N₄O · 338.4466 g/mol (avg)
Code names: MIP 2204 · SH 31072 B

Resolves to

Compound

UNIIE0QN3D755OCAS18016-80-3ChEMBLCHEMBL157138ChEBI51164PubChem28864KEGGD08132

Clinical / RWD

RxNorm6446ATCG02CB02ATCN02CA07PharmGKBPA164749019

Structure

InChIKeyBKRGVLQUQGGVSM-KBXCAEBGSA-NSMILES[H][C@@]12CC3=CNC4=CC=CC(=C34)C1=C[C@@H](CN2C)NC(=O)N(CC)CC

Targets

P14416DRD2P35462DRD3P21917DRD4P28223HTR2AP28335HTR2CP21728DRD1P21918DRD5P08908HTR1A+7 more

What you can answer from here — as of September 23, 2026

15Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1,371Drug interactionsStructured to mechanism, not free text

5Clinical trialsPhase, status and sponsor resolved per trial

2ATC codesIncluding every combination product, plus 30 drug categories

44+ReferencesStructured and connected to the statements they support

Which drugs share a target with Lisuride, and which of those have an active Phase 3 trial?

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