Receptor-type tyrosine-protein kinase FLT3

BE0000147ProteinHumansFLT3

Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. It is acted on by 57 drugs in DrugBank.

Gene name
FLT3
UniProtKB entry
P36888Swiss-Prot
Cellular location
Membrane
Residues / weight
993 residues · 112,903 Da
Also known as
2.7.10.1 · CD135 · Fetal liver kinase-2 · FL cytokine receptor · FLK-2

Resolves to

Protein
UniProtP36888UniProt nameFLT3_HUMAN
Gene
HGNCHGNC:3765NCBI Gene2322GenBank409573GeneCardsFLT3
Pharmacology
IUPHAR/GtoPdb1807KEGGhsa:2322
Structure
PDB1RJBPDB3QS7PDB3QS9
Drugs

What you can answer from here — as of September 07, 2019

57DrugsApproved to experimental, with action, bond type and pharmacological action
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100Clinical trialsTrials of drugs acting on it, by phase and status
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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199+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Receptor-type tyrosine-protein kinase FLT3, how selective are they, and which programs against it are still in active trials?

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