Platelet-derived growth factor receptor beta

BE0000205ProteinHumansPDGFRB

Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival,... It is acted on by 40 drugs in DrugBank.

Gene name
PDGFRB
UniProtKB entry
P09619Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,106 residues · 123,967 Da
Also known as
2.7.10.1 · Beta platelet-derived growth factor receptor · Beta-type platelet-derived growth factor receptor · CD140 antigen-like family member B · PDGF-R-beta

Resolves to

Protein
UniProtP09619UniProt namePGFRB_HUMAN
Gene
HGNCHGNC:8804NCBI Gene5159GenBank189732GeneCardsPDGFRB
Pharmacology
IUPHAR/GtoPdb1804KEGGhsa:5159
Structure
PDB1GQ5PDB1H9OPDB1SHA
Drugs

What you can answer from here — as of September 07, 2019

40DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
45Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
15GO termsFunction, process and component, as structured annotations
Sign in
4Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
174+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Platelet-derived growth factor receptor beta, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In