Gamma-glutamyl hydrolase

BE0000265ProteinHumansGGH

Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. It is acted on by 2 drugs in DrugBank.

Gene name
GGH
UniProtKB entry
Q92820Swiss-Prot
Cellular location
Secreted, extracellular space
Residues / weight
318 residues · 35,964 Da
Also known as
3.4.19.9 · Conjugase · Gamma-Glu-X carboxypeptidase · GH

Resolves to

Protein
UniProtQ92820UniProt nameGGH_HUMAN
Gene
HGNCHGNC:4248NCBI Gene8836GenBank2951931GeneCardsGGH
Pharmacology
KEGGhsa:8836
Structure
PDB1L9X
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-glutamyl hydrolase, how selective are they, and which programs against it are still in active trials?

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