Ribonucleoside-diphosphate reductase large subunit

BE0000325ProteinHumansRRM1

Provides the precursors necessary for DNA synthesis. It is acted on by 10 drugs in DrugBank.

Gene name
RRM1
UniProtKB entry
P23921Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
792 residues · 90,069 Da
Also known as
1.17.4.1 · Ribonucleoside-diphosphate reductase subunit M1 · Ribonucleotide reductase large subunit · RR1

Resolves to

Protein
UniProtP23921UniProt nameRIR1_HUMAN
Gene
HGNCHGNC:10451NCBI Gene6240GenBank36065GeneCardsRRM1
Pharmacology
IUPHAR/GtoPdb2630KEGGhsa:6240
Structure
PDB2WGHPDB3HNCPDB3HND
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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14GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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44+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ribonucleoside-diphosphate reductase large subunit, how selective are they, and which programs against it are still in active trials?

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