Enoyl-[acyl-carrier-protein] reductase [NADH]

BE0000332ProteinMycobacterium tuberculosisinhA

Enoyl-ACP reductase of the type II fatty acid syntase (FAS-II) system, which is involved in the biosynthesis of mycolic acids, a major component of mycobacterial cell walls (PubMed:25227413). It is acted on by 23 drugs in DrugBank.

Gene name
inhA
UniProtKB entry
P9WGR1Swiss-Prot
Residues / weight
269 residues · 28,528 Da
Also known as
1.3.1.9 · ENR · FAS-II enoyl-ACP reductase · NADH-dependent 2-trans-enoyl-ACP reductase

Resolves to

Protein
UniProtP9WGR1UniProt nameINHA_MYCTU
Gene
NCBI Gene886523
Pharmacology
KEGGmtu:Rv1484
Structure
PDB1BVRPDB1ENYPDB1ENZ
Drugs

What you can answer from here — as of September 07, 2019

23DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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74+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Enoyl-[acyl-carrier-protein] reductase [NADH], how selective are they, and which programs against it are still in active trials?

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