ALK tyrosine kinase receptor

BE0000359ProteinHumansALK

Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404,... It is acted on by 20 drugs in DrugBank.

Gene name
ALK
UniProtKB entry
Q9UM73Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,620 residues · 176,441 Da
Also known as
2.7.10.1 · Anaplastic lymphoma kinase

Resolves to

Protein
UniProtQ9UM73UniProt nameALK_HUMAN
Gene
HGNCHGNC:427NCBI Gene238GenBank2454168GeneCardsALK
Pharmacology
IUPHAR/GtoPdb1839KEGGhsa:238
Structure
PDB2KUPPDB2KUQPDB2XB7
Drugs

What you can answer from here — as of September 07, 2019

20DrugsApproved to experimental, with action, bond type and pharmacological action
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115Clinical trialsTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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107+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ALK tyrosine kinase receptor, how selective are they, and which programs against it are still in active trials?

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