X-376

DB13104InvestigationalSmall molecule

X-376 is an inhibitor of the anaplastic lymphoma kinase (ALK) which can penetrate the blood brain barrier. A medication used to treat certain types of lung cancer.

Chemical structure of X-376
Formula / weight
C25H25Cl2FN6O3 · 547.41 g/mol (avg)
Also known as
(R)-6-Amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-(4-methylpiperazine-1-carbonyl)phenyl)pyridazine-3-carboxamide
Code names
X-376

Resolves to

Compound
UNII7DR7JMB8BHCAS1365267-27-1ChEMBLCHEMBL2376648PubChem56960447
Structure
InChIKeyONPGOSVDVDPBCY-CQSZACIVSA-NSMILESC[C@@H](OC1=CC(=NN=C1N)C(=O)NC1=CC=C(C=C1)C(=O)N1CCN(C)CC1)C1=C(Cl)C=CC(F)=C1Cl
Targets
Q9UM73ALK

What you can answer from here — as of August 31, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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39Drug interactionsStructured to mechanism, not free text
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2+ReferencesStructured and connected to the statements they support
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Which drugs share a target with X-376, and which of those have an active Phase 3 trial?

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