Coagulation factor IX

BE0000364ProteinHumansF9

Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa... It is acted on by 29 drugs in DrugBank.

Gene name
F9
UniProtKB entry
P00740Swiss-Prot
Cellular location
Secreted
Residues / weight
461 residues · 51,778 Da
Also known as
3.4.21.22 · Christmas factor · Plasma thromboplastin component · PTC

Resolves to

Protein
UniProtP00740UniProt nameFA9_HUMAN
Gene
HGNCHGNC:3551NCBI Gene2158GenBank182609GeneCardsF9
Pharmacology
IUPHAR/GtoPdb2364KEGGhsa:2158
Structure
PDB1CFHPDB1CFIPDB1EDM
Drugs

What you can answer from here — as of September 07, 2019

29DrugsApproved to experimental, with action, bond type and pharmacological action
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17Clinical trialsTrials of drugs acting on it, by phase and status
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2GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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144+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Coagulation factor IX, how selective are they, and which programs against it are still in active trials?

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