Vitamin K-dependent protein C

BE0000380ProteinHumansPROC

Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265, PubMed:39880037). It is acted on by 13 drugs in DrugBank.

Gene name
PROC
UniProtKB entry
P04070Swiss-Prot
Cellular location
Secreted
Residues / weight
461 residues · 52,071 Da
Also known as
3.4.21.69 · Anticoagulant protein C · Autoprothrombin IIA · Blood coagulation factor XIV

Resolves to

Protein
UniProtP04070UniProt namePROC_HUMAN
Gene
HGNCHGNC:9451NCBI Gene5624GenBank190334GeneCardsPROC
Pharmacology
IUPHAR/GtoPdb2396KEGGhsa:5624
Structure
PDB1AUTPDB1LQVPDB3F6U
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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70+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Vitamin K-dependent protein C, how selective are they, and which programs against it are still in active trials?

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