Vidofludimus

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Vidofludimus
Accession Number
DB15446
Description

Vidofludimus is under investigation in clinical trial NCT03722576 (Vidofludimus Calcium for Primary Sclerosing Cholangitis).

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 355.365
Monoisotopic: 355.121986227
Chemical Formula
C20H18FNO4
Synonyms
Not Available
External IDs
  • IMU-838

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Product Ingredients
IngredientUNIICASInChI Key
Vidofludimus CalciumFW5VY7926X1354012-90-0KWSJBFAXOPFZSO-UHFFFAOYSA-L

Categories

Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
8Y1PJ3VG81
CAS number
717824-30-1
InChI Key
XPRDUGXOWVXZLL-UHFFFAOYSA-N
InChI
InChI=1S/C20H18FNO4/c1-26-14-5-2-4-12(10-14)13-8-9-18(17(21)11-13)22-19(23)15-6-3-7-16(15)20(24)25/h2,4-5,8-11H,3,6-7H2,1H3,(H,22,23)(H,24,25)
IUPAC Name
2-({3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl}carbamoyl)cyclopent-1-ene-1-carboxylic acid
SMILES
COC1=CC(=CC=C1)C1=CC=C(NC(=O)C2=C(CCC2)C(O)=O)C(F)=C1

References

General References
Not Available
ChemSpider
7995757
BindingDB
16111
ChEMBL
CHEMBL197194
ZINC
ZINC000014960644
PDBe Ligand
D5H
PDB Entries
5y1j

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2Active Not RecruitingTreatmentRelapsing Remitting Multiple Sclerosis (RRMS)1
2RecruitingTreatmentCOVID 19 / Novel Coronavirus Infectious Disease (COVID-19)1
2RecruitingTreatmentPrimary Sclerosing Cholangitis (PSC)1
2RecruitingTreatmentUlcerative Colitis1
2, 3RecruitingTreatmentNovel Coronavirus Infectious Disease (COVID-19)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00413 mg/mLALOGPS
logP3.36ALOGPS
logP3.8ChemAxon
logS-4.9ALOGPS
pKa (Strongest Acidic)3.07ChemAxon
pKa (Strongest Basic)-1.4ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area75.63 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity96.21 m3·mol-1ChemAxon
Polarizability35.31 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on May 20, 2019 09:32 / Updated on July 10, 2020 21:45

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