Brequinar

DB03523InvestigationalSmall molecule

Brequinar: Overview.

Mechanism: Pharmacologically active on Dihydroorotate dehydrogenase (quinone), mitochondrial
Curator reviewed
Formula / weight: C₂₃H₁₅F₂NO₂ · 375.3675 g/mol (avg)

Resolves to

Compound

Structure

InChIKeyPHEZJEYUWHETKO-UHFFFAOYSA-NSMILESCC1=C(N=C2C=CC(F)=CC2=C1C(O)=O)C1=CC=C(C=C1)C1=CC=CC=C1F

Targets

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

400Drug interactionsStructured to mechanism, not free text

4Clinical trialsPhase, status and sponsor resolved per trial

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with Brequinar, and which of those have an active Phase 3 trial?

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