All-trans-retinol dehydrogenase [NAD(+)] ADH1B

BE0000400ProteinHumansADH1B

Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism (PubMed:15369820, PubMed:16787387). It is acted on by 13 drugs in DrugBank.

Gene name
ADH1B
UniProtKB entry
P00325Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
375 residues · 39,835 Da
Also known as
1.1.1.105 · ADH2 · Alcohol dehydrogenase 1B · Alcohol dehydrogenase subunit beta

Resolves to

Protein
UniProtP00325UniProt nameADH1B_HUMAN
Gene
HGNCHGNC:250NCBI Gene125GenBank178098GeneCardsADH1B
Pharmacology
KEGGhsa:125
Structure
PDB1DEHPDB1HDXPDB1HDY
Drugs

What you can answer from here — as of September 03, 2024

13DrugsApproved to experimental, with action, bond type and pharmacological action
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3Metabolic reactionsDrug transformations it catalyses, substrate to product
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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49+ReferencesStructured and connected to the statements they support
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Which approved drugs act on All-trans-retinol dehydrogenase [NAD(+)] ADH1B, how selective are they, and which programs against it are still in active trials?

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