Monocarboxylate transporter 4

BE0000449ProteinHumansSLC16A3

Proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate (PubMed:11101640, PubMed:23935841, PubMed:31719150). It is acted on by 14 drugs in DrugBank.

Gene name
SLC16A3
UniProtKB entry
O15427Swiss-Prot
Cellular location
Cell membrane
Residues / weight
465 residues · 49,469 Da
Also known as
MCT 4 · MCT3 · MCT4 · Solute carrier family 16 member 3

Resolves to

Protein
UniProtO15427UniProt nameMOT4_HUMAN
Gene
HGNCHGNC:10924NCBI Gene9123GenBank2463634GeneCardsSLC16A3
Pharmacology
IUPHAR/GtoPdb989KEGGhsa:9123
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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34+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Monocarboxylate transporter 4, how selective are they, and which programs against it are still in active trials?

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