Aldehyde dehydrogenase 1A1

BE0000554ProteinHumansALDH1A1

Cytosolic dehydrogenase that catalyzes the NAD(+)-dependent irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:25450233, PubMed:26373694, PubMed:22339434, PubMed:23444097). It is acted on by 10 drugs in DrugBank.

Gene name
ALDH1A1
UniProtKB entry
P00352Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
501 residues · 54,861 Da
Also known as
1.2.1.19 · 1.2.1.28 · 1.2.1.3 · 1.2.1.36 · 3-deoxyglucosone dehydrogenase

Resolves to

Protein
UniProtP00352UniProt nameAL1A1_HUMAN
Gene
HGNCHGNC:402NCBI Gene216GenBank178372GeneCardsALDH1A1
Pharmacology
KEGGhsa:216
Structure
PDB4WB9PDB4WJ9PDB4WP7
Drugs

What you can answer from here — as of September 03, 2024

10DrugsApproved to experimental, with action, bond type and pharmacological action
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3Metabolic reactionsDrug transformations it catalyses, substrate to product
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17GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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34+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aldehyde dehydrogenase 1A1, how selective are they, and which programs against it are still in active trials?

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