Oxyfedrine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name

Oxyfedrine

DrugBank Accession Number

DB13398

Background

Not Available

Type

Small Molecule

Groups

Experimental

Structure

Similar Structures

Weight: Average: 313.397
Monoisotopic: 313.167793605
Chemical Formula: C₁₉H₂₃NO₃

Synonyms

Oxyfedrine

Pharmacology

Indication: Not Available
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Pharmacodynamics: Not Available
Mechanism of action: Not Available
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half-life: Not Available
Clearance: Not Available
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Toxicity: Not Available
Pathways: Not Available
Pharmacogenomic Effects/ADRs: Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Acebutolol	The therapeutic efficacy of Oxyfedrine can be decreased when used in combination with Acebutolol.
Aceclofenac	The risk or severity of hypertension can be increased when Aceclofenac is combined with Oxyfedrine.
Acemetacin	The risk or severity of hypertension can be increased when Oxyfedrine is combined with Acemetacin.
Acetylsalicylic acid	The risk or severity of hypertension can be increased when Acetylsalicylic acid is combined with Oxyfedrine.
Aclidinium	The risk or severity of Tachycardia can be increased when Aclidinium is combined with Oxyfedrine.
Adenosine	The risk or severity of Tachycardia can be increased when Adenosine is combined with Oxyfedrine.
Alclofenac	The risk or severity of hypertension can be increased when Alclofenac is combined with Oxyfedrine.
Alfentanil	The risk or severity of hypertension can be increased when Alfentanil is combined with Oxyfedrine.
Alfuzosin	The therapeutic efficacy of Oxyfedrine can be decreased when used in combination with Alfuzosin.
Aliskiren	Oxyfedrine may decrease the antihypertensive activities of Aliskiren.

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Food Interactions

Not Available

Chemical Identifiers

UNII: DWL616XF1K
CAS number: 15687-41-9
InChI Key: GDYUVHBMFVMBAF-LIRRHRJNSA-N
InChI: InChI=1S/C19H23NO3/c1-14(19(22)15-7-4-3-5-8-15)20-12-11-18(21)16-9-6-10-17(13-16)23-2/h3-10,13-14,19-20,22H,11-12H2,1-2H3/t14-,19-/m0/s1
IUPAC Name: 3-{[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-(3-methoxyphenyl)propan-1-one
SMILES: COC1=CC(=CC=C1)C(=O)CCN[C@@H](C)[C@H](O)C1=CC=CC=C1

References

General References

Not Available

External Links

ChemSpider: 4590049
RxNav: 7805
ChEBI: 135343
ChEMBL: CHEMBL1651913
ZINC: ZINC000002018339
Wikipedia: Oxyfedrine

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count

Pharmacoeconomics

Manufacturers: Not Available
Packagers: Not Available
Dosage Forms: Not Available
Prices: Not Available
Patents: Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.0217 mg/mL	ALOGPS
logP	2.39	ALOGPS
logP	2.63	Chemaxon
logS	-4.2	ALOGPS
pKa (Strongest Acidic)	13.88	Chemaxon
pKa (Strongest Basic)	9.06	Chemaxon
Physiological Charge	1	Chemaxon
Hydrogen Acceptor Count	4	Chemaxon
Hydrogen Donor Count	2	Chemaxon
Polar Surface Area	58.56 Å²	Chemaxon
Rotatable Bond Count	8	Chemaxon
Refractivity	90.75 m³·mol^-1	Chemaxon
Polarizability	34.91 Å³	Chemaxon
Number of Rings	2	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	Yes	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted GC-MS Spectrum - GC-MS	Predicted GC-MS	Not Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	Not Available

Drug created at June 23, 2017 20:41 / Updated at February 21, 2021 18:54

Oxyfedrine

Identification

Structure for Oxyfedrine (DB13398)

Pharmacology

Interactions

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra