Aldo-keto reductase family 1 member C3

BE0000592ProteinHumansAKR1C3

Cytosolic aldo-keto reductase that catalyzes NADPH-dependent reduction of ketosteroids to hydroxysteroids. It is acted on by 19 drugs in DrugBank.

Gene name
AKR1C3
UniProtKB entry
P42330Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
323 residues · 36,853 Da
Also known as
1.1.1.- · 1.1.1.210 · 1.1.1.53 · 1.1.1.62 · 17-beta-HSD 5

Resolves to

Protein
UniProtP42330UniProt nameAK1C3_HUMAN
Gene
HGNCHGNC:386NCBI Gene8644GenBank4261711GeneCardsAKR1C3
Pharmacology
IUPHAR/GtoPdb1382KEGGhsa:8644
Structure
PDB1RY0PDB1RY8PDB1S1P
Drugs

What you can answer from here — as of September 07, 2019

19DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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7Metabolic reactionsDrug transformations it catalyses, substrate to product
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16GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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51+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aldo-keto reductase family 1 member C3, how selective are they, and which programs against it are still in active trials?

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