Aldo-keto reductase family 1 member C2

BE0000622ProteinHumansAKR1C2

Cytosolic aldo-keto reductase that catalyzes NADPH-dependent reduction of ketosteroids to hydroxysteroids. It is acted on by 12 drugs in DrugBank.

Gene name
AKR1C2
UniProtKB entry
P52895Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
323 residues · 36,735 Da
Also known as
1.1.1.112 · 1.1.1.209 · 1.1.1.51 · 1.1.1.62 · 1.3.1.20

Resolves to

Protein
UniProtP52895UniProt nameAK1C2_HUMAN
Gene
HGNCHGNC:385NCBI Gene1646GenBank531160GeneCardsAKR1C2
Pharmacology
KEGGhsa:1646
Structure
PDB1IHIPDB1J96PDB1XJB
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
4Metabolic reactionsDrug transformations it catalyses, substrate to product
Sign in
14GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
34+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Aldo-keto reductase family 1 member C2, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In