Potassium voltage-gated channel subfamily KQT member 1

BE0000672ProteinHumansKCNQ1

Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of cardiomyocyte excitability and important in normal development and functions of myocardium, inner ear, stomach and colon (PubMed:10646604, PubMed:25441029). It is acted on by 10 drugs in DrugBank.

Gene name
KCNQ1
UniProtKB entry
P51787Swiss-Prot
Cellular location
Cell membrane
Residues / weight
676 residues · 74,698 Da
Also known as
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 · KCNA8 · KCNA9 · KQT-like 1 · KVLQT1

Resolves to

Protein
UniProtP51787UniProt nameKCNQ1_HUMAN
Gene
HGNCHGNC:6294NCBI Gene3784GenBank2465531GeneCardsKCNQ1
Pharmacology
IUPHAR/GtoPdb560KEGGhsa:3784
Structure
PDB12DKPDB3BJ4PDB3HFC
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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41GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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79+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Potassium voltage-gated channel subfamily KQT member 1, how selective are they, and which programs against it are still in active trials?

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