Glutathione S-transferase Mu 1

BE0000807ProteinHumansGSTM1

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. It is acted on by 18 drugs in DrugBank.

Gene name
GSTM1
UniProtKB entry
P09488Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
218 residues · 25,712 Da
Also known as
2.5.1.18 · GST class-mu 1 · GST HB subunit 4 · GST1 · GSTM1-1

Resolves to

Protein
UniProtP09488UniProt nameGSTM1_HUMAN
Gene
HGNCHGNC:4632NCBI Gene2944GenBank31924GeneCardsGSTM1
Pharmacology
KEGGhsa:2944
Structure
PDB1GTUPDB1XW6PDB1XWK
Drugs

What you can answer from here — as of September 07, 2019

18DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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3Metabolic reactionsDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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46+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutathione S-transferase Mu 1, how selective are they, and which programs against it are still in active trials?

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