Glutamate receptor 4

BE0000830ProteinHumansGRIA4

Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). It is acted on by 11 drugs in DrugBank.

Gene name
GRIA4
UniProtKB entry
P48058Swiss-Prot
Cellular location
Cell membrane
Residues / weight
902 residues · 100,870 Da
Also known as
AMPA-selective glutamate receptor 4 · GluA4 · GluR-4 · GluR-D · GLUR4

Resolves to

Protein
UniProtP48058UniProt nameGRIA4_HUMAN
Gene
HGNCHGNC:4574NCBI Gene2893GenBank790538GeneCardsGRIA4
Pharmacology
IUPHAR/GtoPdb447KEGGhsa:2893
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamate receptor 4, how selective are they, and which programs against it are still in active trials?

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