Sulfotransferase 1E1

BE0000951ProteinHumansSULT1E1

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:11006110, PubMed:11884392, PubMed:7779757). It is acted on by 11 drugs in DrugBank.

Gene name
SULT1E1
UniProtKB entry
P49888Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
294 residues · 35,126 Da
Also known as
2.8.2.4 · EST-1 · Estrogen sulfotransferase · ST1E1 · STE

Resolves to

Protein
UniProtP49888UniProt nameST1E1_HUMAN
Gene
HGNCHGNC:11377NCBI Gene6783GenBank488283GeneCardsSULT1E1
Pharmacology
KEGGhsa:6783
Structure
PDB1G3MPDB1HY3PDB4JVL
Drugs

What you can answer from here — as of September 03, 2024

11DrugsApproved to experimental, with action, bond type and pharmacological action
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8Metabolic reactionsDrug transformations it catalyses, substrate to product
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sulfotransferase 1E1, how selective are they, and which programs against it are still in active trials?

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