Fatty acid synthase

BE0000959ProteinHumansFASN

Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. It is acted on by 11 drugs in DrugBank.

Gene name
FASN
UniProtKB entry
P49327Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
2,511 residues · 273,424 Da
Also known as
2.3.1.85 · FAS · Type I fatty acid synthase

Resolves to

Protein
UniProtP49327UniProt nameFAS_HUMAN
Gene
HGNCHGNC:3594NCBI Gene2194GenBank1049053GeneCardsFASN
Pharmacology
IUPHAR/GtoPdb2608KEGGhsa:2194
Structure
PDB1XKTPDB2CG5PDB2JFD
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
4Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
11Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
43+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Fatty acid synthase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In