Transforming growth factor beta-1 proprotein

BE0000984ProteinHumansTGFB1

Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. It is acted on by 20 drugs in DrugBank.

Gene name
TGFB1
UniProtKB entry
P01137Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix
Residues / weight
390 residues · 44,325 Da
Also known as
TGFB

Resolves to

Protein
UniProtP01137UniProt nameTGFB1_HUMAN
Gene
HGNCHGNC:11766NCBI Gene7040GenBank1212989GeneCardsTGFB1
Pharmacology
KEGGhsa:7040
Structure
PDB1KLAPDB1KLCPDB1KLD
Drugs

What you can answer from here — as of September 03, 2024

20DrugsApproved to experimental, with action, bond type and pharmacological action
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16Clinical trialsTrials of drugs acting on it, by phase and status
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73GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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73+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transforming growth factor beta-1 proprotein, how selective are they, and which programs against it are still in active trials?

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