Interleukin-2

BE0001029ProteinHumansIL2

Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance (PubMed:6438535). It is acted on by 20 drugs in DrugBank.

Gene name
IL2
UniProtKB entry
P60568Swiss-Prot
Cellular location
Secreted
Residues / weight
153 residues · 17,628 Da
Also known as
IL-2 · T-cell growth factor · TCGF

Resolves to

Protein
UniProtP60568UniProt nameIL2_HUMAN
Gene
HGNCHGNC:6001NCBI Gene3558GenBank5729676GeneCardsIL2
Pharmacology
KEGGhsa:3558
Structure
PDB1IRLPDB1M47PDB1M48
Drugs

What you can answer from here — as of September 07, 2019

20DrugsApproved to experimental, with action, bond type and pharmacological action
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106Clinical trialsTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interleukin-2, how selective are they, and which programs against it are still in active trials?

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