Identification

Generic Name
Girentuximab
DrugBank Accession Number
DB05304
Background

Girentuximab is a monoclonal chimeric (mouse/human) antibody directed against carbonic anhydrase IX, an antigen expressed in 95% of clear cell renal cell carcinomas (RCC).

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • Girentuximab
External IDs
  • CA9-SCAN CG250
  • cG 250
  • cG250
  • WX G250
  • WX-G 250
  • WX-G250

Pharmacology

Indication

Investigated for use/treatment in gall bladder cancer and renal cell carcinoma.

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action

Mechanism of action of girentuximab is antibody dependent cellular cytotoxicity (ADCC). As a monotherapy in metastatic renal cell carcinomas(RCC), girentuximab demonstrated minimal clinical activity with a 3% partial response rate and a median survival of 16 months. In vitro data suggest that the number of activated ADCC effector cells can be upregulated by low dose interleukin 2 (IL2) administered in a pulsatile fashion.

TargetActionsOrganism
UCarbonic anhydrase 9Not AvailableHumans
UInterleukin-2Not AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbciximabThe risk or severity of adverse effects can be increased when Abciximab is combined with Girentuximab.
AdalimumabThe risk or severity of adverse effects can be increased when Adalimumab is combined with Girentuximab.
AducanumabThe risk or severity of adverse effects can be increased when Girentuximab is combined with Aducanumab.
AlemtuzumabThe risk or severity of adverse effects can be increased when Alemtuzumab is combined with Girentuximab.
AlirocumabThe risk or severity of adverse effects can be increased when Girentuximab is combined with Alirocumab.
AmivantamabThe risk or severity of adverse effects can be increased when Girentuximab is combined with Amivantamab.
AnifrolumabThe risk or severity of adverse effects can be increased when Girentuximab is combined with Anifrolumab.
AnsuvimabThe risk or severity of adverse effects can be increased when Girentuximab is combined with Ansuvimab.
Anthrax immune globulin humanThe risk or severity of adverse effects can be increased when Girentuximab is combined with Anthrax immune globulin human.
Antilymphocyte immunoglobulin (horse)The risk or severity of adverse effects can be increased when Girentuximab is combined with Antilymphocyte immunoglobulin (horse).
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Food Interactions
Not Available

Products

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International/Other Brands
Rencarex

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
539B57DFJF
CAS number
916138-87-9

References

General References
  1. Carney WP: Circulating oncoproteins HER2/neu, EGFR and CAIX (MN) as novel cancer biomarkers. Expert Rev Mol Diagn. 2007 May;7(3):309-19. [Article]
PubChem Substance
347910066
Wikipedia
Girentuximab

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentRenal Cancers1
3WithdrawnDiagnosticRenal Cancers / Renal Cell Carcinoma1
2CompletedTreatmentMetastatic Clear Cell Renal Cell Carcinoma (ccRCC)1
2RecruitingTreatmentAdvanced Renal Cell Carcinoma (aRCC) / Clear Cell Renal Cell Carcinoma (ccRCC) / Renal Cancers1
2, 3CompletedDiagnosticRenal Cell Carcinoma1
1CompletedTreatmentNeoplasms, Kidney / Renal Cancers / Renal Cell Carcinoma1
1RecruitingDiagnosticRenal Cell Carcinoma1
1RecruitingDiagnosticUrothelial Carcinoma1
1TerminatedTreatmentRenal Cell Carcinoma1
1, 2CompletedTreatmentMetastatic Renal Cell Carcinoma ( mRCC)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Targets

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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervic...
Gene Name
CA9
Uniprot ID
Q16790
Uniprot Name
Carbonic anhydrase 9
Molecular Weight
49697.36 Da
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Kinase activator activity
Specific Function
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimu...
Gene Name
IL2
Uniprot ID
P60568
Uniprot Name
Interleukin-2
Molecular Weight
17627.52 Da

Drug created at November 18, 2007 18:23 / Updated at February 21, 2021 18:51