Trace amine-associated receptor 1

BE0001044ProteinHumansTAAR1

Intracellular G protein-coupled receptor for trace amines, which recognizes endogenous amine-containing metabolites such as beta-phenylethylamine (beta-PEA), 3-iodothyronamine (T1AM), isoamylamine (IAA), cadaverine (CAD), cyclohexylamine (CHA), p-tyramine (p-TYR), trimethylamine (TMA), octopamine and tryptamine (PubMed:11459929, PubMed:11723224, PubMed:15718104, PubMed:31399635,... It is acted on by 11 drugs in DrugBank.

Gene name
TAAR1
UniProtKB entry
Q96RJ0Swiss-Prot
Cellular location
Endomembrane system
Residues / weight
339 residues · 39,091 Da
Also known as
TA1 · TaR-1 · TAR1 · Trace amine receptor 1 · TRAR1

Resolves to

Protein
UniProtQ96RJ0UniProt nameTAAR1_HUMAN
Gene
HGNCHGNC:17734NCBI Gene134864GenBank14600074GeneCardsTAAR1
Pharmacology
IUPHAR/GtoPdb364KEGGhsa:134864
Structure
PDB8JLNPDB8JLOPDB8JLP
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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47+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Trace amine-associated receptor 1, how selective are they, and which programs against it are still in active trials?

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