Glucose-6-phosphate 1-dehydrogenase

BE0001089ProteinHumansG6PD

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. It is acted on by 11 drugs in DrugBank.

Gene name
G6PD
UniProtKB entry
P11413Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
515 residues · 59,256 Da
Also known as
1.-.-.- · 1.1.1.49 · G6PD

Resolves to

Protein
UniProtP11413UniProt nameG6PD_HUMAN
Gene
HGNCHGNC:4057NCBI Gene2539GenBank31543GeneCardsG6PD
Pharmacology
KEGGhsa:2539
Structure
PDB1QKIPDB2BH9PDB2BHL
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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38Clinical trialsTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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60+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glucose-6-phosphate 1-dehydrogenase, how selective are they, and which programs against it are still in active trials?

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