16-Bromoepiandrosterone is an injectable formulation of a compound called alpha-epi-bromide. It is a chemical relative of DHEA which was selected for development after it showed antiretroviral activity in laboratory tests.
- Mechanism
- Curator reviewed
HE2000 interacts with certain enzymes, including G6PDH (glucose 6 phosphate dehydrogenase); these enzymes could be involved in the mechanism. Also, the compound is in the steroid hormone series, and involved in control mechanisms in our cells that are much more complex, interacting with receptors and therefore changing the biochemistry of cells. This compound may have many modes of action; we are trying to understand what they may be.
- Primary indication
- Investigated for use/treatment in cystic fibrosis, HIV infection, hepatitis (viral, B), and malaria.Curator reviewed
- Formula / weight
- C19H29BrO2 · 369.336 g/mol (avg)
- Code names
- HE-2000
Resolves to
CWVMWSZEMZOUPC-JUAXIXHSSA-NSMILES[H][C@@]12C[C@@H](Br)C(=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@@H](O)CC[C@]12CWhat you can answer from here — as of January 29, 2025
Which drugs share a target with 16-Bromoepiandrosterone, and which of those have an active Phase 3 trial?
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