Neutrophil collagenase

BE0001182ProteinHumansMMP8

Can degrade fibrillar type I, II, and III collagens. It is acted on by 25 drugs in DrugBank.

Gene name
MMP8
UniProtKB entry
P22894Swiss-Prot
Cellular location
Cytoplasmic granule
Residues / weight
467 residues · 53,412 Da
Also known as
3.4.24.34 · CLG1 · Matrix metalloproteinase-8 · MMP-8 · PMNL collagenase

Resolves to

Protein
UniProtP22894UniProt nameMMP8_HUMAN
Gene
HGNCHGNC:7175NCBI Gene4317GenBank180618GeneCardsMMP8
Pharmacology
IUPHAR/GtoPdb1632KEGGhsa:4317
Structure
PDB1A85PDB1A86PDB1BZS
Drugs

What you can answer from here — as of September 07, 2019

25DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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62+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Neutrophil collagenase, how selective are they, and which programs against it are still in active trials?

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