Metabotropic glutamate receptor 5

BE0001192ProteinHumansGRM5

G protein-coupled receptor for glutamate. It is acted on by 17 drugs in DrugBank.

Gene name
GRM5
UniProtKB entry
P41594Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,212 residues · 132,468 Da
Also known as
GPRC1E · MGLUR5

Resolves to

Protein
UniProtP41594UniProt nameGRM5_HUMAN
Gene
HGNCHGNC:4597NCBI Gene2915GenBank1408052GeneCardsGRM5
Pharmacology
IUPHAR/GtoPdb293KEGGhsa:2915
Structure
PDB3LMKPDB4OO9PDB5CGC
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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40GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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46+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Metabotropic glutamate receptor 5, how selective are they, and which programs against it are still in active trials?

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