Macrophage metalloelastase

BE0001198ProteinHumansMMP12

May be involved in tissue injury and remodeling. It is acted on by 22 drugs in DrugBank.

Gene name
MMP12
UniProtKB entry
P39900Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix
Residues / weight
470 residues · 54,001 Da
Also known as
3.4.24.65 · HME · Macrophage elastase · Matrix metalloproteinase-12 · ME

Resolves to

Protein
UniProtP39900UniProt nameMMP12_HUMAN
Gene
HGNCHGNC:7158NCBI Gene4321GenBank435970GeneCardsMMP12
Pharmacology
IUPHAR/GtoPdb1636KEGGhsa:4321
Structure
PDB1JIZPDB1JK3PDB1OS2
Drugs

What you can answer from here — as of September 07, 2019

22DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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48+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Macrophage metalloelastase, how selective are they, and which programs against it are still in active trials?

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